For several years now, PFAS have regularly made headlines in health and environmental news. Contaminated drinking water, polluted soil, everyday products called into question… These substances are causing growing concern.
Why are they referred to as “forever chemicals”? Are they truly dangerous? And how are we exposed to them in our daily lives?

PFAS (per- and polyfluoroalkyl substances) include several thousand synthetic molecules developed starting in the 1950s.
Their chemical specificity lies in the carbon-fluorine bond, one of the strongest known. This stability gives them sought-after properties: resistance to heat, water, grease, and chemicals.
But this same stability creates a major problem: PFAS break down extremely slowly in the environment.
They are therefore called “forever chemicals” because they persist for decades, or even longer, in soil, water, air, and living organisms. Once released, they circulate and accumulate.
PFAS have been widely used in many industrial sectors and consumer products.
They can be found in:
This wide range of uses explains their widespread presence in the environment. Emissions may come from industrial facilities, contaminated sites, or the resuspension of urban dust. Even after the production of certain molecules has stopped, their persistence continues to contribute to exposure.

There is not just one PFAS, but several thousand compounds, with varying toxicological profiles. However, for some of the most studied ones, associations have been established with several concerning health effects.
Scientific research notably points to:
It is important to note that not all molecules have the same level of scientific evidence. However, their persistent and bioaccumulative nature raises a major public health concern. The challenge also lies in chronic exposure to low doses over long periods of time.
Today, ingestion is the main route of exposure for the general population. The most affected foods include:

Drinking water can also be a significant source of exposure in certain regions. PFAS can migrate into food from soil, irrigation water, or packaging. Their ability to accumulate along the food chain explains the higher levels found in some animal-based products.
Although water and food are the main routes of exposure, air is not free from contamination.
Studies have detected PFAS in ambient air, particularly near industrial sites or former areas where firefighting foams were used. These substances can also be found in household dust.
Inhalation represents a less dominant route of exposure than ingestion, but it is clearly identified. However, data remain limited, as PFAS monitoring campaigns in air are still underdeveloped and specific regulatory values are rare. This means that part of the overall exposure is still poorly characterized.
Beyond their health impacts, PFAS generate considerable environmental and economic costs. Expenses related to healthcare, environmental monitoring, soil and water remediation, and the management of contaminated sites amount to very high sums at the international level.
Some estimates suggest that cumulative costs could reach several hundred billion euros by 2050 in Europe in the absence of stronger restrictions. The issue therefore goes beyond the individual level: it concerns the overall management of environmental risk.
HEPA (High Efficiency Particulate Air) filters, used in air purifiers and certain air handling units, are designed to capture fine particles and protect occupants from many pollutants.
However, some HEPA filter designs use PTFE (polytetrafluoroethylene) membranes or ePTFE (expanded PTFE). PTFE belongs to the fluoropolymer family, which is itself classified among per- and polyfluoroalkyl substances (PFAS) under the broad scope of European regulatory definitions (ECHA).
It is important to distinguish between several situations:

To date, there is no robust evidence showing significant emissions of PFAS into indoor air from HEPA filters under normal use conditions. The main issue identified by European authorities relates more to the overall environmental persistence of PFAS and to reducing emissions throughout their life cycle.
There is nevertheless an interesting paradox: a device designed to protect indoor air can, in certain technological configurations, incorporate materials that belong to the “forever chemicals” family.
This does not mean that these filters constitute a major source of exposure, but it highlights the growing importance of an approach that integrates:
PFAS are persistent synthetic substances that have been widely used for more than 70 years and are now present in all environmental compartments: water, soil, air, and the food chain. Exposure occurs mainly through food and drinking water, but also through air and dust.
Although not all molecules are equally well documented, several PFAS are associated with significant health effects. Their persistence and accumulation justify the current regulatory debates and increasing monitoring efforts. Understanding these mechanisms helps to better grasp the health, environmental, and economic challenges linked to these “forever chemicals.”
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